Now this time, let’s see if we can do the same with FTDI (FT232H) IC driving hardware directly without any MCU in between. FT232H/FT2232H MPSSE mode for I2C. Newer FTDI IC s such as FT232H or FT2232H came with MPSSE mode built-in, which can implement common data protocols such as SPI, I2C and more. Our device uses the FTDI D2XX drivers. The Anywhere USB will not maintain a persistent connection to the FTDI USB device over the network. The connection drops intermittently. There are many threads on the forums related to compatibility issues between the AnywhereUSB and FTDI drivers but no solutions are offered.
Provided software is pretty much what I've come to expect out of these things - worthless. It's standard Windows only and/or .Net code which might be possible to get building via Mono. DRControl (google it) happens to work if you're using python. It's FTDI, so rolling your own shouldn't be too much effort.