Several single sample gene-set enrichment analysis methods have been introduced to score samples against gene expression signatures, such as ssGSEA, GSVA...ISCB - International Society for Computational Biology. Shuhua Fu, University of Iowa, United States; Yingke Ma, University of Iowa, United States; Hui Yao, Peking Union Medical College, Beijing 100193, China, China
Jul 11, 2019 · The ssGSEA method computes the enrichment score of a given gene set for a single sample. The ssGSEA method and the original GSEA method are similar [ 7 ], but they use different gene score values. In the original GSEA method, gene score values are usually fold change of different contexts.